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## Main links, portals, etc.: ##
* Wikipedia articles [on the
outbreak](https://en.wikipedia.org/wiki/2019%E2%80%9320_coronavirus_outbreak),
[on the
virus](https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2)
and [on the disease it
causes](https://en.wikipedia.org/wiki/Coronavirus_disease_2019).
* [Daily situation
reports](https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/)
and [general
updates](https://www.who.int/emergencies/diseases/novel-coronavirus-2019)
by the WHO.
* [Covid-19 global cases situation dashboard by John
Hopkins](https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6) (and [mobile version](https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/85320e2ea5424dfaaa75ae62e5c06e61)),
updated daily ([historical
data](https://github.com/CSSEGISandData/COVID-19)).
* [Covid-19 coronavirus section on
Worldometer](https://www.worldometers.info/coronavirus/).
* [Covid-19 page by Our World in
Data](https://ourworldindata.org/coronavirus).
* Epidemic data by Wolfram Data [for the
world](https://www.wolframcloud.com/obj/examples/COVID19World) and
[for China](https://www.wolframcloud.com/obj/examples/COVID19China).
* [Temporal variation in the reproduction number, rate of spread, and
doubling time during the course of the COVID-19
outbreak](https://epiforecasts.io/covid/posts/global/) by the Centre
for Mathematical Modelling of Infectious Diseases.
* [Covid-19 epidemic
forecasting](https://renkulab.shinyapps.io/COVID-19-Epidemic-Forecasting/_w_5f9d45a0/_w_8da5e02a/?tab=world_map)
by the Institute of Global Health, Faculty of Medicine, University
of Geneva and the Swiss Data Science Center, ETH Zürich-EPFL.
* [Covid-19 projections using Machine
Learning](https://covid19-projections.com/) created by Youyang Gu.
* [Phylogenetic tree of 2019-nCoV
strains](https://nextstrain.org/ncov) on Nextstrain ([data
source](https://github.com/nextstrain/ncov)).
* [Virus pathogen data portal on
2019-nCoV](https://www.viprbrc.org/brc/home.spg?decorator=corona_ncov).
* [CSV and JSON files with case counts per country, compiled
daily](https://www.data.gouv.fr/fr/datasets/coronavirus-covid19-evolution-par-pays-et-dans-le-monde-maj-quotidienne/) \[metadata in French\].
* [SARS-CoV-2 (Covid-19) by the
numbers](https://github.com/milo-lab/SARS-CoV-2/raw/master/versions/SARS-CoV-2_BTN.pdf)
fact sheet (updated regularly).
* [COVID-19 Open Research Dataset
(CORD-19)](https://pages.semanticscholar.org/coronavirus-research)
by Semantic Scholar.
* [Bibliovid: veille scientifique sur
Covid-19](https://bibliovid.org/) \[in French\].
* [MedCram series of medical
lectures](https://www.youtube.com/user/MEDCRAMvideos/videos) with
frequent updates on the epidemic.
## Country-specific links ##
* France
* Epidemiological summary in France:
[2020-03-15](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-15-mars-2020),
[2020-03-24](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-24-mars-2020),
[2020-04-02](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-2-avril-2020),
[2020-04-09](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-9-avril-2020),
[2020-04-16](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-16-avril-2020),
[2020-04-23](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-23-avril-2020),
[2020-04-30](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-30-avril-2020),
[2020-05-07](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-7-mai-2020),
[2020-05-14](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-14-mai-2020),
[2020-05-21](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-21-mai-2020),
[2020-05-29](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-29-mai-2020),
[2020-06-04](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-4-juin-2020),
[2020-06-11](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-11-juin-2020),
[2020-06-18](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-18-juin-2020),
[2020-06-25](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-25-juin-2020),
[2020-07-02](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-2-juillet-2020),
[2020-07-09](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-9-juillet-2020),
[2020-07-16](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-16-juillet-2020),
[2020-07-23](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-23-juillet-2020),
[2020-07-30](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-30-juillet-2020),
[2020-08-06](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-6-aout-2020),
[2020-08-13](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-13-aout-2020),
[2020-08-20](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-20-aout-2020),
[2020-08-27](https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/bulletin-national/covid-19-point-epidemiologique-du-27-aout-2020).
* Epidemiological monitoring data set: [from emergency
services](https://www.data.gouv.fr/fr/datasets/donnees-des-urgences-hospitalieres-et-de-sos-medecins-relatives-a-lepidemie-de-covid-19/)
and [from hospitals](https://www.data.gouv.fr/fr/datasets/donnees-hospitalieres-relatives-a-lepidemie-de-covid-19/).
* [Géodes](https://geodes.santepubliquefrance.fr/) (graphical tool
to display, compare and export epidemiological data sets and
indicators).
* [Avis du conseil scientifique Covid-19](https://solidarites-sante.gouv.fr/actualites/presse/dossiers-de-presse/article/covid-19-_conseil-scientifique-covid-19)
* Italy
* [Epidemiological monitoring data set](https://github.com/pcm-dpc/COVID-19/)
## Topical or time-specific links: ##
* [Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten
million residents of Wuhan,
China](https://www.nature.com/articles/s41467-020-19802-w) (*Nature
Communications*, 2020-11-20). “We describe a city-wide SARS-CoV-2
nucleic acid screening programme between May 14 and June 1, 2020 in
Wuhan. […] There were no positive tests amongst 1174 close contacts
of asymptomatic cases.”
* [Immunological memory to SARS-CoV-2 assessed for greater than six
months after
infection](https://www.biorxiv.org/content/10.1101/2020.11.15.383323v1)
(2020-11-16 preprint). [Twitter
thread](https://twitter.com/profshanecrotty/status/1328760517184212993)
by last author summarizing results: “The upshot is that there is
substantial immune memory after COVID-19.”
* [Mobility network models of COVID-19 explain inequities and inform
reopening](https://www.nature.com/articles/s41586-020-2923-3)
(*Nature*, 2020-11-10). Attempts to use fine-grained mobility data
derived from cell phone networks in 10 of the largest US
metropolitan statistical areas to model the proportion of infections
at various types of locations.
* [High prevalence of pre-existing serological cross-reactivity
against SARS-CoV-2 in sub-Sahara
Africa](https://www.ijidonline.com/article/S1201-9712(20)32310-9/fulltext)
(*Int. J. Infect. Diseases*, 2020-11-07). “Low SARS-CoV-2 infection
and disease in SSA \[Sub-Saharan Africa\] appears to correlate with
pre-pandemic serological cross-recognition of HCoVs \[NL63 and
229E\], which are substantially more prevalent in SSA than USA.”
* [Evolution of Antibody Immunity to
SARS-CoV-2](https://www.biorxiv.org/content/10.1101/2020.11.03.367391v1)
(2020-11-05 preprint). “The observation that memory B cell
responses do not decay after 6.2 months, but instead continue to
evolve, is strongly suggestive that individuals who are infected
with SARS-CoV-2 could mount a rapid and effective response to the
virus upon re-exposure.”
* [Humoral Immune Response to SARS-CoV-2 in
Iceland](https://www.nejm.org/doi/full/10.1056/NEJMoa2026116) (NEJM,
2020-10-29). Conclusions: “Our results indicate that antiviral
antibodies against SARS-CoV-2 did not decline within 4 months after
diagnosis. We estimate that the risk of death from infection was
0.3% and that 44% of persons infected with SARS-CoV-2 in Iceland
were not diagnosed by qPCR.”
* [Robust neutralizing antibodies to SARS-CoV-2 infection persist for
months](https://science.sciencemag.org/content/early/2020/10/27/science.abd7728)
(*Science* report, 2020-10-28). “We also show that titers are
relatively stable for at least a period approximating 5 months and
that anti-spike binding titers significantly correlate with
neutralization of authentic SARS-CoV-2. Our data suggests that more
than 90% of seroconverters make detectible neutralizing antibody
responses. These titers remain relatively stable for several months
after infection.”
* [Virology, transmission, and pathogenesis of
SARS-CoV-2](https://www.bmj.com/content/371/bmj.m3862) (*British
Medical Journal* clinical update, 2020-10-23): an overview of what
is currently known about SARS-CoV-2 transmission, pathology and
immunity.
* [The effect of influenza vaccination on trained immunity: impact on
COVID-19](https://www.medrxiv.org/content/10.1101/2020.10.14.20212498v1)
(2020-10-16 preprint). Conclusion: “a quadrivalent inactivated
influenza vaccine can induce trained immunity responses against
SARS-CoV-2, which may result in relative protection against
COVID-19. These data […] argue for a beneficial effect of influenza
vaccination against influenza as well as COVID-19, and suggests its
effective deployment in the 2020-2021 influenza season to protect
against both infections.”
* [Infection fatality rate of COVID-19 inferred from seroprevalence
data](https://www.who.int/bulletin/online_first/BLT.20.265892.pdf)
(*Bulletin of the WHO*, 2020-10-14) by Dr. John Ioannidis. “The
infection fatality rate of COVID-19 can vary substantially across
different locations and this may reflect differences in population
age structure and case-mix of infected and deceased patients and
other factors. The inferred infection fatality rates tended to be
much lower than estimates made earlier in the pandemic.”
* [Less severe course of COVID-19 is associated with elevated levels
of antibodies against seasonal human coronaviruses OC43 and HKU1
(HCoV OC43, HCoV
HKU1)](https://www.medrxiv.org/content/10.1101/2020.10.12.20211599v1)
(2020-10-14 preprint). “Our results indicate that previous
infections with seasonal coronaviruses might protect against a
severe course of disease. This finding should be validated in other
settings and could contribute to identify persons at risk before an
infection.”
* [Global perspective of COVID‐19 epidemiology for a full‐cycle
pandemic](https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.13423)
(*European Journal of Clinical Investigation*, 2020-10-07).
Provides a global perspective on the pandemic. Simulations are
presented with a total of 1.58 to 8.76 million COVID-19 deaths over
5 years globally.
* [Assessment of the risk of SARS-CoV-2 reinfection in an intense
re-exposure
setting](https://www.medrxiv.org/content/10.1101/2020.08.24.20179457v2)
(2020-09-28 preprint). Conclusions: “SARS-CoV-2 reinfection can
occur but is a rare phenomenon suggestive of a strong protective
immunity against reinfection that lasts for at least a few months
post primary infection.”
* [Covid-19: Do many people have pre-existing
immunity?](https://www.bmj.com/content/370/bmj.m3563) (*British
Medical Journal* feature, 2020-09-17). “It seemed a truth
universally acknowledged that the human population had no
pre-existing immunity to SARS-CoV-2, but is that actually the case?
Peter Doshi explores the emerging research on immunological
responses.”
* [COVID-19 and the Path to
Immunity](https://jamanetwork.com/journals/jama/fullarticle/2770758)
(JAMA Viewpoint, 2020-09-11). Summarizes various aspects of immune
response to Covid-19 infection, and its durability.
* [A Basic Review of the Preliminary Evidence That COVID-19 Risk and
Severity Is Increased in Vitamin D
Deficiency](https://www.frontiersin.org/articles/10.3389/fpubh.2020.00513/full)
(*Frontiers in Public Health*, 2020-09-10). “Among the 47 original
research studies summarized here, chart reviews found that serum
vitamin D levels predicted COVID-19 mortality rates (16 studies) and
linearly predicted COVID-19 illness severity (8 studies). […] Widely
recommending 2,000 IU of vitamin D daily for all populations with
limited ability to manufacture vitamin D from the sun has virtually
no potential for harm and is reasonably likely to save many lives.”
* [Use of “normal” risk to improve understanding of dangers of
covid-19](https://www.bmj.com/content/370/bmj.m3259.full) (*British
Medical Journal* analysis, 2020-09-09). Compares risk of dying by
Covid-19 to “normal” (i.e., baseline mortality) risk for various age
groups, suggesting that “being infected with SARS-CoV-2 contributes
about a year's worth of extra risk of dying for those aged over 20”
\[a phrase which has been considerably misinterpreted\].
* [Immunological characteristics govern the changing severity of
COVID-19 during the transition to
endemicity](https://www.medrxiv.org/content/10.1101/2020.09.03.20187856v1)
(2020-09-05 preprint). “Our model recapitulates both the current
severity of CoV-2 and the relatively benign nature of HCoVs;
suggesting that once the endemic phase is reached, CoV-2 may be no
more virulent than the common cold.”
* [Are we underestimating seroprevalence of
SARS-CoV-2?](https://www.bmj.com/content/370/bmj.m3364) (*British
Medical Journal* editorial, 2020-09-03). Emphasizes the fact that
SARS-CoV-2 seroprevalence studies show considerable variation and
may underestimate true seroprevalence; and encourages testing for
IgA antibodies.
* [Humoral Immune Response to SARS-CoV-2 in
Iceland](https://www.nejm.org/doi/full/10.1056/NEJMoa2026116) (NEJM,
2020-09-01). Conclusion: “Our results indicate that antiviral
antibodies against SARS-CoV-2 did not decline within 4 months after
diagnosis. We estimate that the risk of death from infection was
0.3% and that 44% of persons infected with SARS-CoV-2 in Iceland
were not diagnosed by qPCR.”
* [Effect of Calcifediol Treatment and best Available Therapy versus
best Available Therapy on Intensive Care Unit Admission and
Mortality Among Patients Hospitalized for COVID-19: A Pilot
Randomized Clinical
study](https://www.sciencedirect.com/science/article/pii/S0960076020302764)
(*J. Steroid Biochem. Molec. Biol.*, 2020-08-29). Highlights: “ The
vitamin D endocrine system may have a variety of actions on cells
and tissues involved in COVID-19 progression. Administration of
calcifediol or 25-hydroxyvitamin D to hospitalized COVID-19 patients
significantly reduced their need for Intensive Care United
admission. Calcifediol seems to be able to reduce severity of the
disease.”
* [Inoculum at the time of SARS-CoV-2 exposure and risk of disease
severity](https://www.sciencedirect.com/science/article/pii/S1201971220304707)
(*J. Infect. Diseases*, 2020-08). “We report three clusters of
individuals that were potentially exposed to distinct inoculum in
Madrid. […] Our data support that a greater viral inoculum at the
time of SARS-CoV-2 exposure might determine a higher risk of severe
COVID-19.”
* [Feline coronavirus drug inhibits the main protease of SARS-CoV-2
and blocks virus
replication](https://www.nature.com/articles/s41467-020-18096-2)
(*Nature*, 2020-08-27). Lays the framework for the use of two
dipeptide-based protease inhibitor (GC376 and GC373), found to be
effective against Feline Enteric Coronavirus (FECoV), in human
trials for the treatment of COVID-19.
* [Two metres or one: what is the evidence for physical distancing in
covid-19?](https://www.bmj.com/content/370/bmj.m3223) (*British
Medical Journal* analysis, 2020-08-25). Argues that “current rules
on safe physical distancing are based on outdated science; rules on
distancing should reflect the multiple factors that affect risk,
including ventilation, occupancy, and exposure time”, and proposes a
table of low/medium/high risk configurations.
* [Progress report on the coronavirus
pandemic](https://www.nature.com/articles/d41586-020-02414-1).
(*Nature* editorial, 2020-08-19).
* [High prevalence of SARS-CoV-2 antibodies in care homes affected by
COVID-19; a prospective cohort study in
England](https://www.medrxiv.org/content/10.1101/2020.08.10.20171413v1)
(2020-08-12 preprint). Finds that older residents are able to mount
the same antibody response and neutralizing antibodies against
SARS-CoV-2 as the younger healthier staff, irrespective of gender or
having symptoms.
* [A country level analysis measuring the impact of government
actions, country preparedness and socioeconomic factors on COVID-19
mortality and related health
outcomes](https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370%2820$2930208-X/fulltext)
(2020-07-21, *EClinicalMedicine*). A country level exploratory
analysis to assess the impact of timing and type of national health
policy/actions undertaken towards COVID-19 mortality and related
health outcomes. Sample finding: “Rapid border closures, full
lockdowns, and wide-spread testing were not associated with COVID-19
mortality per million people.”
* [The impact of host resistance on cumulative mortality and the
threshold of herd immunity for
SARS-CoV-2](https://www.medrxiv.org/content/10.1101/2020.07.15.20154294v1)
(2020-07-16 preprint). Key finding: “\[Herd immunity threshold\]
may be greatly reduced if a fraction of the population is unable to
transmit the virus due to innate resistance or cross-protection from
exposure to seasonal coronaviruses”.
* [Robust T cell immunity in convalescent individuals with
asymptomatic or mild
COVID-19](https://www.biorxiv.org/content/10.1101/2020.06.29.174888v1)
(2020-06-29 preprint). Key finding: “Our collective dataset shows
that SARS-CoV-2 elicits robust memory T cell responses akin to those
observed in the context of successful vaccines, suggesting that
natural exposure or infection may prevent recurrent episodes of
severe COVID-19 also in seronegative individuals.”
* [Syrian hamsters as a small animal model for SARS-CoV-2 infection
and countermeasure
development](https://www.pnas.org/content/117/28/16587). “We
assessed the replicative ability and pathogenesis of SARS-CoV-2
isolates in Syrian hamsters. SARS-CoV-2 isolates replicated
efficiently in the lungs of hamsters, causing severe pathological
lung lesions following intranasal infection. In addition,
microcomputed tomographic imaging revealed severe lung injury that
shared characteristics with SARS-CoV-2−infected human lung,
including severe, bilateral, peripherally distributed, multilobular
ground glass opacity, and regions of lung consolidation.
SARS-CoV-2−infected hamsters mounted neutralizing antibody responses
and were protected against subsequent rechallenge with
SARS-CoV-2. […] Collectively, these findings demonstrate that this
Syrian hamster model will be useful for understanding SARS-CoV-2
pathogenesis and testing vaccines and antiviral drugs.”
* [Intrafamilial Exposure to SARS-CoV-2 Induces Cellular Immune
Response without
Seroconversion](https://www.medrxiv.org/content/10.1101/2020.06.21.20132449v1)
(2020-06-20 preprint). Conclusion: “Exposure to SARS-CoV-2 can
induce virus-specific T cell responses without seroconversion. T
cell responses may be more sensitive indicators of SARS-Co-V-2
exposure than antibodies. Our results indicate that epidemiological
data relying only on the detection of SARS-CoV-2 antibodies may lead
to a substantial underestimation of prior exposure to the virus.”
* [Systemic and mucosal antibody secretion specific to SARS-CoV-2
during mild versus severe
COVID-19](https://www.biorxiv.org/content/10.1101/2020.05.21.108308v1)
(2020-05-23 preprint). Main conclusion: “Data show that systemic
IgA and IgG production against SARS-CoV-2 develops mainly in severe
COVID-19, with very high IgA levels seen in patients with severe
ARDS, whereas mild disease may be associated with transient serum
titers of SARS-CoV-2-specific antibodies but stimulate mucosal
SARS-CoV-2-specific IgA secretion. The findings suggest four grades
of antibody responses dependent on COVID-19 severity.”
\[Note that around the end of May I stopped maintaining this list.
Still adding a few papers later, but it's definitely less complete
than it used to be.\]
* [Hydroxychloroquine or chloroquine with or without a macrolide for
treatment of COVID-19: a multinational registry
analysis](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2820%2931180-6)
(2020-05-22, *The Lancet*). Key finding: were unable to confirm a
benefit of hydroxychloroquine or chloroquine, when used alone or
with a macrolide, on in-hospital outcomes for COVID-19. Each of
these drug regimens was associated with decreased in-hospital
survival and an increased frequency of ventricular arrhythmias when
used for treatment of COVID-19.
* [Individual variation in susceptibility or exposure to SARS-CoV-2
lowers the herd immunity
threshold](https://www.medrxiv.org/content/10.1101/2020.04.27.20081893v2)
(2020-05-12 preprint) suggests a lowering of herd immunity due to
population heterogeneity.
* [OpenSAFELY: factors associated with COVID-19-related hospital death
in the linked electronic health records of 17 million adult NHS
patients](https://www.medrxiv.org/content/10.1101/2020.05.06.20092999v1)
(2020-05-07 preprint), a statistical analysis of 17M medical records
to compute risk factors for death from Covid-19. ⚔ [Twitter
thread](https://twitter.com/EpiEllie/status/1258607277357006849)
criticizing the analysis for possibility of “M bias”. [Another such
thread](https://twitter.com/bristimtom/status/1259458854020165632).
* [The disease-induced herd immunity level for Covid-19 is
substantially lower than the classical herd immunity
level](https://arxiv.org/abs/2005.03085) (2020-05-06 preprint)
suggests a lowering of herd immunity due to population
heterogeneity.
* [The invisible
pandemic](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31035-7/fulltext)
(The Lancet correspondence, 2020-05-05). Johan Giesecke explains
and argues the case for Sweden's strategy: “a lockdown might delay
severe cases for a while, but once restrictions are eased, cases
will reappear”.
* [Immunology of COVID-19: current state of the
science](https://www.cell.com/immunity/fulltext/S1074-7613%2820%2930183-7)
(2020-05-05, *Cell Immunity*), a review of the state of knowledge
concerning innate and adaptive immune responses elicited by
SARS-CoV-2 infection.
* [Lockdown exit strategies and risk of a second epidemic peak: a
stochastic agent-based model of SARS-CoV-2 epidemic in
France](https://www.medrxiv.org/content/10.1101/2020.04.30.20086264v1)
(2020-05-05 preprint), a detailed model of the post-lockdown phase
in France.
* [What settings have been linked to SARS-CoV-2 transmission
clusters?](https://wellcomeopenresearch.org/articles/5-83)
(2020-05-01, open peer review) identifies possible places linked to
clusters of Covid-19 cases. Key finding: many examples of
SARS-CoV-2 clusters linked to a wide range of mostly indoor
settings: few reports came from schools, many from households, and
an increasing number were reported in hospitals and elderly care
settings across Europe.
* [Changes in contact patterns shape the dynamics of the COVID-19
outbreak in
China](https://science.sciencemag.org/content/early/2020/04/28/science.abb8001)
(2020-04-29, Science report). From the abstract: “Daily contacts
were reduced 7–8-fold during the COVID-19 social distancing period,
with most interactions restricted to the household. We find that
children 0–14 years are less susceptible to SARS-CoV-2 infection
than adults 15–64 years of age (odd ratio 0.34, 95%CI 0.24–0.49),
while in contrast, individuals over 65 years are more susceptible to
infection (odd ratio 1.47, 95%CI: 1.12–1.92).”
* [The race for coronavirus vaccines: a graphical
guide](https://www.nature.com/articles/d41586-020-01221-y)
(2020-04-28, Nature news feature), illustrating eight ways in which
scientists hope to provide immunity to SARS-CoV-2.
* [SARS-CoV-2 serological analysis of COVID-19 hospitalized patients,
pauci-symptomatic individuals and blood
donors](https://www.medrxiv.org/content/10.1101/2020.04.21.20068858v1)
(2020-04-24) by the Institut Pasteur. Studies the levels of
anti-SARS-CoV-2 antibodies in hospitalized patients versus
pauci-symptomatic individuals versus blood donors.
* [Cluster of COVID-19 in northern France: A retrospective closed
cohort
study](https://www.medrxiv.org/content/10.1101/2020.04.18.20071134v1)
(2020-04-23) by the Institut Pasteur. Analyses the results of
antibody detection tests on blood samples from a cluster connected
to the high school of Crépy-en-Valois, finding an attack rate of
26%.
* [Covid-19: one-month impact of the French lockdown on the epidemic
burden](https://www.ea-reperes.com/wp-content/uploads/2020/04/ImpactConfinement-EHESP-20200322v1.pdf)
(2020-04-22) modelling by EHESP team.
* [The potential danger of suboptimal antibody responses in
COVID-19](https://www.nature.com/articles/s41577-020-0321-6)
(2020-04-21, Nature Immunology) discusses antibody-dependent
enhancement and how this impacts potential vaccine development.
* [Estimating the burden of SARS-CoV-2 in
France](https://hal-pasteur.archives-ouvertes.fr/pasteur-02548181)
(2020-04-21) by the Institut Pasteur. Among conclusions, finds that
lockdown reduced the reproductive number from 3.3 to 0.5, and that
5.7% of the population will have been infected by May 11. *\[Move
this to the country-specific section?\]*
* [Persistence and efficiency of antibodies against SARS-CoV-2: the
state of current
knowledge](https://www.vidal.fr/actualites/24770/persistance_et_efficacite_des_anticorps_neutralisants_contre_le_sars_cov_2_etat_des_connaissances_et_lecons_des_autres_coronavirus_humains/) (2020-04-20 \[in French\]).
* [Estimating the overdispersion in COVID-19 transmission using
outbreak sizes outside
China](https://wellcomeopenresearch.org/articles/5-67) (2020-04-09,
open peer review) attempts to estimate variance in COVID-19
transmission rates by modeling secondary transmission rates as a
negative-binomial distribution with mean R₀ in the 2–3 consensus
range and estimating the overdispersion parameter. Key finding: the
overdispersion parameter k of a negative-binomial distribution was
estimated to be around 0.1, suggesting that 80% of secondary
transmissions may have been caused by a small fraction of infectious
individuals (~10%).
* [Indoor transmission of
SARS-CoV-2](https://www.medrxiv.org/content/10.1101/2020.04.04.20053058v1)
(2020-04-07 preprint) confirms that sharing indoor place is the
major Covid-19 infection risk, and analyses circumstances.
* [Effectiveness of convalescent plasma therapy in severe COVID-19
patients](https://www.pnas.org/content/early/2020/04/02/2004168117)
(2020-04-06, PNAS) ⚔ [Twitter thread discussing
this](https://twitter.com/DrEricDing/status/1248059832038502402).
* [Baseline Characteristics and Outcomes of 1591 Patients Infected
With SARS-CoV-2 Admitted to ICUs of the Lombardy Region,
Italy](https://jamanetwork.com/journals/jama/fullarticle/2764365)
(2020-04-06, JAMA).
* [Respiratory virus shedding in exhaled breath and efficacy of face
masks](https://www.nature.com/articles/s41591-020-0843-2) (Nature
brief communication, 2020-04-03).
* [“Coronavirus: Bad News Wrapped in Protein” infographic by the New
York
Times](https://www.nytimes.com/interactive/2020/04/03/science/coronavirus-genome-bad-news-wrapped-in-protein.html)
(2020-04-03), illustrating the proteins coded for by the SARS-CoV-2
genome and what function they (are thought to) have.
* [Virological assessment of hospitalized patients with
Covid-19](https://www.nature.com/articles/s41586-020-2196-x)
(2020-04-01, *Nature*), virological analysis of nine cases focusing
on virus replication and shedding in the upper respiratory tract.
* [Immune responses in COVID-19 and potential vaccines: Lessons
learned from SARS and MERS
epidemic](http://apjai-journal.org/wp-content/uploads/2020/03/1.pdf),
review article in Asian Pacific Journal of Allergy and Immunology
(2020-03, vol. 38).
* [Estimating the number of infections and the impact of
non-pharmaceutical interventions on Covid-19 in 11 European
countries](https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-COVID19-Europe-estimates-and-NPI-impact-30-03-2020.pdf)
(2020-03-30) by the Imperial College Covid-19 Response Team.
* [Coronavirus: the key numbers we must find
out](https://medium.com/@davidbessis/coronavirus-the-core-metrics-we-should-be-looking-at-2ca09a3dc4b1)
(2020-03-26 Medium piece by David Bessis) emphasizes how little we
know of the fatality ratio of Covid-19.
* [Perspectives on the Pandemic by Dr. John
Ioannidis](https://www.youtube.com/watch?v=ZEr4rmjwd0g) (2020-03-25)
cautions against making decisions without reliable data (e.g.,
regarding fatality rate) (an extension of Dr. Ioannidis's 2020-03-17
[“Fiasco in the making?” opinion
piece](https://www.statnews.com/2020/03/17/a-fiasco-in-the-making-as-the-coronavirus-pandemic-takes-hold-we-are-making-decisions-without-reliable-data/)
in *Stat News*).
* [Using a delay-adjusted case fatality ratio to estimate
under-reporting](https://cmmid.github.io/topics/covid19/severity/global_cfr_estimates.html)
(2020-03-22) by the Centre for Mathematical Modelling of Infectious
Diseases.
* [The early phase of the COVID-19 outbreak in Lombardy,
Italy](https://arxiv.org/abs/2003.09320) (2020-03-20 preprint),
epidemiological characterization of the first 5830 lab-confirmed
cases.
* [A thread about immunity by Nicholas
A. Christakis](https://threadreaderapp.com/thread/1240689935557865472.html)
(2020-03-20) explaining what we now know and don't know.
* [A thread about
favipiravir](https://threadreaderapp.com/thread/1240261123712126978.html)
(2020-03-18) as a possible treatment of Covid-19.
* [The proximal origin of
SARS-CoV-2](https://www.nature.com/articles/s41591-020-0820-9)
(Nature Medicine correspondence, 2020-03-17).
* [Global Covid-19 Case Fatality
Rates](https://www.cebm.net/covid-19/global-covid-19-case-fatality-rates/)
(2020-03-17, regularly updated), an estimation of CFR and IFR by the
University of Oxford's Centre for Evidence-Based Medicine.
* [Aerosol and surface stability of SARS-CoV-2 as compared to
SARS-CoV-1](https://www.nejm.org/doi/full/10.1056/NEJMc2004973)
(Letter in NEJM, 2020-03-17).
* [Excess cases of Influenza like illnesses in France synchronous with
Covid-19
invasion](https://www.medrxiv.org/content/10.1101/2020.03.14.20035741v1)
(2020-03-17 preprint), suggest larger circulation of SARS-CoV-2 in
the French population than apparent from confirmed cases. ⁂ See also
[this Twitter
thread](https://twitter.com/FLAHAULT/status/1240337073531506690) for
analogous observations in various countries.
* [Covid-19 ou la chronique d'une émergence
annoncée](https://www.college-de-france.fr/site/actualites/Covid-19ChroniqueEmergenceAnnoncee.htm)
(conference at the Collège de France, 2020-03-16, \[in French\]).
* [Breadth of concomitant immune responses prior to patient recovery:
a case report of non-severe
COVID-19](https://www.nature.com/articles/s41591-020-0819-2) (Nature
correspondence, 2020-03-16).
* [Forecasting short-term hospital needs in
France](https://www.ea-reperes.com/wp-content/uploads/2020/03/PredictedFrenchHospitNeeds-EHESP-20200316.pdf) (2020-03-16).
* [Impact of non-pharmaceutical interventions to reduce Covid-19
mortality and healthcare
demand](https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-COVID19-NPI-modelling-16-03-2020.pdf)
(2020-03-16) by the Imperial College Covid-19 Response Team.
* [Substantial undocumented infection facilitates the rapid
dissemination of novel coronavirus
(SARS-CoV2)](https://science.sciencemag.org/content/early/2020/03/13/science.abb3221), published in *Science* (2020-03-16).
* [Reinfection could not occur in SARS-CoV-2 infected rhesus
macaques](https://www.biorxiv.org/content/10.1101/2020.03.13.990226v1)
(2020-03-14 preprint) assesses the immunity to SARS-CoV-2 from a
first infection in the case of rhesus macaque monkeys.
* [The convalescent sera option for containing
COVID-19](https://www.jci.org/articles/view/138003) (Journal of
Clinical Investigation, 2020-03-13) argues that human convalescent
serum is an option for prevention and treatment of COVID-19 disease
that could be rapidly available when there are sufficient numbers of
people who have recovered.
* [Early epidemiological assessment of the transmission potential and
virulence of Covid-19 in Wuhan City
China](https://www.medrxiv.org/content/10.1101/2020.02.12.20022434v2)
(2020-03-13 preprint) estimates that the proportion of infected
people in Wǔhàn was far larger than estimated (and the fatality rate
far lower than estimated).
* [Coronavirus: Why it's so deadly in
Italy](https://medium.com/@andreasbackhausab/coronavirus-why-its-so-deadly-in-italy-c4200a15a7bf)
(2020-03-13 Medium piece), emphasizes the role of demographics.
* [Estimates of the severity of COVID-19
disease](https://www.medrxiv.org/content/10.1101/2020.03.09.20033357v1)
(2020-03-13 preprint) puts the overall IFR at 0.7% and gives a
breakdown per age group.
* [How will country-based mitigation measures influence the course of
the Covid-19
epidemic?](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2820%2930567-5/fulltext)
(2020-03-09), a comment in The Lancet with a general discussion of
the state of the epidemic and possible strategies.
* American Hospital Association's “Best Guess Epidemiology” has been
[reported on
Twitter](https://twitter.com/sethbannon/status/1236125593290276864)
on 2020-03-07, estimating a disease burden of ~10× severe flu season
(attack rate ~30–40%, of which 5% requiring hospitalization, 1–2%
requiring ICU, 0.5% fatal).
* [How to contain an
epidemic](https://www.franceculture.fr/emissions/la-methode-scientifique/la-methode-scientifique-emission-du-vendredi-06-mars-2020),
radio broadcast on 2020-03-06 \[in French\] with infectiologist
Anne-Claude Crémieux and epidemiologist Arnaud Fontanet.
* [General information meeting about Covid-19 at the
Sorbonne](https://www.youtube.com/watch?v=nWRKNKnt0ig) (2020-03-05).
* [Etimation of infection and case fatality ratios for Covid-19 using
data from Diamond
Princess](https://cmmid.github.io/topics/covid19/severity/diamond_cruise_cfr_estimates.html)
by the Centre for Mathematical Modelling of Infectious Diseases,
online 2020-03-05.
* [Serial interval of novel coronavirus (COVID-19)
infections](https://www.ijidonline.com/article/S1201-9712(20)30119-3),
published 2020-03-04, estimates the median serial interval at 4.0
days.
* [Persistence of coronaviruses on inanimate surfaces and their
inactivation with biocidal
agents](https://www.sciencedirect.com/science/article/pii/S0195670120300463),
published 2020-03 (not specific to SARS-CoV-2).
* [Twitter thread by Nicholas
A. Christakis](https://twitter.com/NAChristakis/status/1235204443362205699)
(on 2020-03-04) on the benefits of closing schools, based on a study
of the effects of the 1918 flu pandemic; key message: closing early
is important.
* [A paper on the origin and continuing evolution of
SARS-CoV-2](https://academic.oup.com/nsr/advance-article/doi/10.1093/nsr/nwaa036/5775463)
published on 2020-03-03 in the National Science Review, discussing
the coexistence of two types of strains, which they call ‘L’ (more
virulent) and ‘S’ (less virulent), the ‘L’ being more prevalent but
the ‘S’ becoming seemingly progressively more frequent because human
actions put more pressure against the more virulent strains. ⚔
[Beware](https://twitter.com/SciTania/status/1235283259510214656)
that the difference in virulence is inferred from propagation rates
rather than observed on clinical data, and the selective pressure
explanation is debatable.
* [Report on monitoring of persons exposed to patients with
Covid-19](https://www.cdc.gov/mmwr/volumes/69/wr/mm6909e1.htm)
published 2020-03-03 in CDC's Morbidity and Mortality Weekly Report:
key finding places symptomatic secondary attack rate at 0.45% among
close contacts and 10.5% among household members. ⚔ Here a [critical
look](https://twitter.com/AdamJKucharski/status/1235124770896826369)
at these figures by epidemiologist Adam Kucharski.
* [The species Severe acute respiratory syndrome-related coronavirus:
classifying 2019-nCoV and naming it
SARS-CoV-2](https://www.nature.com/articles/s41564-020-0695-z)
(Nature Microbiology Consensus Statement, 2020-03-02).
* [SARS-Cov-2 and the lessons we have to learn from
it](https://medium.com/@edwardnirenberg/sars-cov-2-and-the-lessons-we-have-to-learn-from-it-e2017fd5d3c),
a well-written general summary by Edward Nirenberg (2020-03-02).
Emphasis: “The real issue is what having this pandemic does to
healthcare systems globally.”
* [A discussion in *Science*
Magazine](https://www.sciencemag.org/news/2020/03/china-s-aggressive-measures-have-slowed-coronavirus-they-may-not-work-other-countries)
(2020-03-02; [Twitter
thread](https://twitter.com/kakape/status/1234603592407044096)) on
[the WHO
report](https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf)
(released 2020-02-28) on the joint WHO-Chinese mission led by Bruce
Aylard to study the state of the epidemic in China; key message: the
measures taken by Chinese authorities to contain the epidemic
worked, but unclear what will happen in the long run or whether they
can be applied in other countries.
* [A fairly detailed FAQ
video](https://www.youtube.com/watch?v=oA8XYSftmtQ) \[[index of
questions at
1′10″](https://www.youtube.com/watch?v=oA8XYSftmtQ#t=1m10s)\]
uploaded on 2020-03-03 by [Inés
Dawson](https://twitter.com/InesLauraDawson). *\[TODO: write some
kind of summary here.\]*
* [Simulation of the effect of extra
hand-washing](https://twitter.com/FryRsquared/status/1234491912775782400)
on the spread of an epidemic (a simulation performed in 2018,
retweeted on 2020-03-02); key message: it really has an impact, not
just on the speed of progression but also on the final attack rate.
* Two hour-long live interviews \[in French\] by Brut: [Arnaud
Fontanet (epidemiologist at the Institut
Pasteur)](https://www.youtube.com/watch?v=vs2oyLSlo0Q) on
2020-02-26, and [Éric Caumes (head of the department of infectious
diseases at the Pitié hospital in
Paris)](https://www.youtube.com/watch?v=L5thFsjoHok) on 2020-02-28.
*\[I didn't have time to watch.\]*
* [Twitter Q&A
thread](https://twitter.com/MackayIM/status/1233509962292375559) by
virologist [Ian M. Mackay](https://virologydownunder.com/) on
2020-02-28; discusses, inter alia, reinfection
([here](https://twitter.com/MackayIM/status/1233512522168356864),
[here](https://twitter.com/MackayIM/status/1233512323358363654) and
[here](https://twitter.com/MackayIM/status/1233511497017561090);
seems to think false recovery is more likely than reinfection),
[attack
rate](https://twitter.com/MackayIM/status/1233511899083530240)
(thinks 70% is probably overestimated), [virus
lifetime](https://twitter.com/MackayIM/status/1233522944137187329),
[fatality rate in
Italy](https://twitter.com/MackayIM/status/1233521001578803200)
(probably seems high because of observation bias) and more.
* [A discussion of seasonality of SARS-CoV-2 by epidemiologist Marc
Lipsitch](https://docs.google.com/document/d/17mWPx-HTE1F2RKkbJlt4VkSYaznUiJgt21nuvmu51Kc)
\[date≤2020-02-26\]; summary: despite seasonality of related
viruses, it probably won't go away on its own in the summer.
* [A primer for the general public on virus
mutation](https://ccdd.hsph.harvard.edu/mutation-adaptation-and-virus-genomes-a-primer-for-the-public/)
\[date≤2020-02-26\]; main message is that we don't know much about
mutations of this particular virus, but mutations aren't
particularly scary in and of themselves.
* [Interview of Éric Caumes (head of the department of infectious
diseases at the Pitié hospital in
Paris)](https://www.jim.fr/e-docs/covid_19_la_riposte_est_elle_plus_redoutable_que_le_virus__181852/document_jim_tube.phtml)
on 2020-02-25 \[in French\], discussing various issues
(contagiousness, attack rate, fatality rate, mutation rate, etc.);
main message seems to be that we are overreacting.
* [Thread by epidemiologist Marc
Lipsitch](https://threadreaderapp.com/thread/1231425805898657795.html)
on 2020-02-23 ([Twitter
link](https://twitter.com/mlipsitch/status/1231425805898657795)),
discussing the possibility and effectiveness of (temporary vs
long-term) countermeasures (case-based containment vs lockdowns,
etc.); expresses skepticism as to effectiveness of Chinese lockdowns
(and reliability of reported figures).
* [What we have learnt as of 2020-02-20, MOOC by epidemiologist Arnaud
Fontanet for the Institut
Pasteur](https://www.youtube.com/watch?v=4l_NxT9XJHk); summarizes
main information as of this date. *\[TODO: write better summary
here.\]*
* [Thread by epidemiologist Marc
Lipsitch](https://threadreaderapp.com/thread/1228373884027592704.html)
on 2020-02-14 ([Twitter
link](https://twitter.com/mlipsitch/status/1228373884027592704)),
discussing attack rate (=cumulated infection rate) r and the
estimation that 40%≲r≲70% “in a situation without effective
controls” based on comparison with similar epidemics.
* [Epidemiological characteristics report published in *China CDC
Weekly*](http://weekly.chinacdc.cn/fileCCDCW/journal/article/ccdcw/newcreate/COVID-19.pdf)
\[[mirror](https://github.com/cmrivers/ncov/blob/master/COVID-19.pdf)\]
detailing breakdown of cases and statistics up to 2020-02-11 (72 314
cases).
## More stuff ##
* [Links to Covid-19 related
articles](https://www.reddit.com/r/Coronavirus/comments/feo68j/humanity_wins_our_fight_to_unlock_32544_covid19/fjpbaph/)
unlocked after pressure on publishers.
## Not Covid-19 specific but still relevant ##
* Definition of [morbidity frequency
measures](https://www.cdc.gov/csels/dsepd/ss1978/lesson3/section2.html)
and [mortality frequency
measures](https://www.cdc.gov/csels/dsepd/ss1978/lesson3/section3.html)
from (online version of) the CDC's book *Principles of Epidemiology
in Public Health Practice*: explains definitions of “attack rate”,
“secondary attack rate”, “case-fatality rate”, etc.
* (Reproduction numbers of infectious disease
models)[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002118/]
comments on the definition of R₀ in various models.
* Wikipedia page about [compartmental models in
epidemiology](https://en.wikipedia.org/wiki/Compartmental_models_in_epidemiology)
such as the SIR model.
* [Epidemiological parameter review and comparative dynamics of
various human respiratory
infections](https://www.medrxiv.org/content/10.1101/2020.02.04.20020404v1).
* [Contacts in context: large-scale setting-specific social mixing
matrices from the BBC *Pandemic*
project](https://www.medrxiv.org/content/10.1101/2020.02.16.20023754v2)
evaluating social mixing data.
## My own explanatory threads on Twitter ##
* [A note concerning herd immunity (unconditional versus conditional
on other
measures)](https://threadreaderapp.com/thread/1324405641268645888.html)
(2020-11-05).
* [A caution regarding how effective reproduction numbers are
computed](https://threadreaderapp.com/thread/1320327001258008578.html)
(2020-10-25).
* [Computation of attack rate in function of variance (dispersion) in
graph
models](https://threadreaderapp.com/thread/1258835372315901952.html) +
[more mathematical
details](https://threadreaderapp.com/thread/1258482878779965440.html)
(2020-05-08).
* [On evidence or lack of evidence that Covid-19 infections confer
immunity](https://threadreaderapp.com/thread/1254069215264419841.html)
and [an epidemiological estimation of the order of magnitude of
immunity conferred by
HCoVs](https://threadreaderapp.com/thread/1254105660440092674.html)
(2020-04-25).
* [Why the variance of infectious contacts received matters more than
the variance of infectious contacts
made](https://threadreaderapp.com/thread/1252581933835575297.html)
(2020-04-21).
* [Problems with the definition of “herd
immunity”](https://threadreaderapp.com/thread/1250817310526525440.html)
(2020-04-16).
* [The problem with using models to predict the
future](https://threadreaderapp.com/thread/1249738327143501824.html)
(2020-04-13).
* [Experiments on the influence of the social graph structure on
attack rates of
epidemics](https://threadreaderapp.com/thread/1241745979663155203.html)
(2020-03-22).
* [Putting the Imperial College paper (by Ferguson &al) in
perspective](https://threadreaderapp.com/thread/1240713126233899008.html)
(2020-03-19).
* [On strategies ① (contain) and ② (mitigate) when dealing with an
epidemic](https://threadreaderapp.com/thread/1237372990540713984.html)
(2020-03-10).
* [On the final attack rate in the SIR epidemic
model](https://threadreaderapp.com/thread/1236324650315059200.html)
(2020-03-07).
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