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| author | David A. Madore <david+git@madore.org> | 2020-10-23 21:18:16 +0200 |
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| committer | David A. Madore <david+git@madore.org> | 2020-10-23 21:18:16 +0200 |
| commit | 8c2366fa9fdfe4203c79b76fe6049caf323178d0 (patch) | |
| tree | 89730213bebbe69309e742cfa19d648f72607ed5 | |
| parent | 781499048ea9f690f57d7f10275f744a18d68f10 (diff) | |
| download | covid19-8c2366fa9fdfe4203c79b76fe6049caf323178d0.tar.gz covid19-8c2366fa9fdfe4203c79b76fe6049caf323178d0.tar.bz2 covid19-8c2366fa9fdfe4203c79b76fe6049caf323178d0.zip | |
Link to two old papers which at least somewhat support the idea of dose-dependent severity.
| -rw-r--r-- | covid19-links.md | 25 |
1 files changed, 25 insertions, 0 deletions
diff --git a/covid19-links.md b/covid19-links.md index 3712ae4..e8f9381 100644 --- a/covid19-links.md +++ b/covid19-links.md @@ -192,6 +192,14 @@ admission. Calcifediol seems to be able to reduce severity of the disease.” +* [Inoculum at the time of SARS-CoV-2 exposure and risk of disease + severity](https://www.sciencedirect.com/science/article/pii/S1201971220304707) + (*J. Infect. Diseases*, 2020-08). “We report three clusters of + individuals that were potentially exposed to distinct inoculum in + Madrid. […] Our data support that a greater viral inoculum at the + time of SARS-CoV-2 exposure might determine a higher risk of severe + COVID-19.” + * [Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication](https://www.nature.com/articles/s41467-020-18096-2) @@ -248,6 +256,23 @@ natural exposure or infection may prevent recurrent episodes of severe COVID-19 also in seronegative individuals.” +* [Syrian hamsters as a small animal model for SARS-CoV-2 infection + and countermeasure + development](https://www.pnas.org/content/117/28/16587). “We + assessed the replicative ability and pathogenesis of SARS-CoV-2 + isolates in Syrian hamsters. SARS-CoV-2 isolates replicated + efficiently in the lungs of hamsters, causing severe pathological + lung lesions following intranasal infection. In addition, + microcomputed tomographic imaging revealed severe lung injury that + shared characteristics with SARS-CoV-2−infected human lung, + including severe, bilateral, peripherally distributed, multilobular + ground glass opacity, and regions of lung consolidation. + SARS-CoV-2−infected hamsters mounted neutralizing antibody responses + and were protected against subsequent rechallenge with + SARS-CoV-2. […] Collectively, these findings demonstrate that this + Syrian hamster model will be useful for understanding SARS-CoV-2 + pathogenesis and testing vaccines and antiviral drugs.” + * [Intrafamilial Exposure to SARS-CoV-2 Induces Cellular Immune Response without Seroconversion](https://www.medrxiv.org/content/10.1101/2020.06.21.20132449v1) |