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admission. Calcifediol seems to be able to reduce severity of the
disease.”
+* [Inoculum at the time of SARS-CoV-2 exposure and risk of disease
+ severity](https://www.sciencedirect.com/science/article/pii/S1201971220304707)
+ (*J. Infect. Diseases*, 2020-08). “We report three clusters of
+ individuals that were potentially exposed to distinct inoculum in
+ Madrid. […] Our data support that a greater viral inoculum at the
+ time of SARS-CoV-2 exposure might determine a higher risk of severe
+ COVID-19.”
+
* [Feline coronavirus drug inhibits the main protease of SARS-CoV-2
and blocks virus
replication](https://www.nature.com/articles/s41467-020-18096-2)
@@ -248,6 +256,23 @@
natural exposure or infection may prevent recurrent episodes of
severe COVID-19 also in seronegative individuals.”
+* [Syrian hamsters as a small animal model for SARS-CoV-2 infection
+ and countermeasure
+ development](https://www.pnas.org/content/117/28/16587). “We
+ assessed the replicative ability and pathogenesis of SARS-CoV-2
+ isolates in Syrian hamsters. SARS-CoV-2 isolates replicated
+ efficiently in the lungs of hamsters, causing severe pathological
+ lung lesions following intranasal infection. In addition,
+ microcomputed tomographic imaging revealed severe lung injury that
+ shared characteristics with SARS-CoV-2−infected human lung,
+ including severe, bilateral, peripherally distributed, multilobular
+ ground glass opacity, and regions of lung consolidation.
+ SARS-CoV-2−infected hamsters mounted neutralizing antibody responses
+ and were protected against subsequent rechallenge with
+ SARS-CoV-2. […] Collectively, these findings demonstrate that this
+ Syrian hamster model will be useful for understanding SARS-CoV-2
+ pathogenesis and testing vaccines and antiviral drugs.”
+
* [Intrafamilial Exposure to SARS-CoV-2 Induces Cellular Immune
Response without
Seroconversion](https://www.medrxiv.org/content/10.1101/2020.06.21.20132449v1)